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The cells of our body integrate signals from multiple stimuli in order to mount appropriate physiological responses. These signals are transmitted to specific targets within the cell by intracellular signalling pathways that employ post-translational modifications, particularly phosphorylation. The fidelity of signal transmission by these pathways and the cross-talk between them are tightly controlled. This unit will cover how key signalling pathways in cells transduce extracellular signals to regulate gene expression and cellular processes such as growth and apoptosis. It will also provide an understanding of how disruption of these pathways can lead to diseases such as cancer and stroke.

• provide an understanding of the mechanisms by which cells communicate • illustrate the commonality and differences in these mechanism using examples of key signalling molecules and pathways • provide a basis for understanding disease processes in which signalling is compromised • give insight into the experimental methods used for studying cell signalling

Students will be able to: • describe the various types of signalling molecules including receptors, adapter proteins, second messengers, kinases and phosphatases • understand how the physical properties of signalling molecules influence their behaviour • describe the major intracellular signalling pathways in cells and have an understanding of their complexity and the interactions between them • have an understanding of the link between extracellular signals and intracellular events, including the regulation of gene expression and apoptosis • discuss the relevance of cell signalling in a variety of physiological and pathological situations • appreciate the experimental techniques associated with the study of cell signalling • research the scientific literature to enhance their knowledge and develop their critical thinking skills.

• Introduction to cell signalling: signalling networks, protein-protein interactions, protein phosphorylation/de-phosphorylation. • Receptors: types of receptor (RTK, GPCR, TGF, cytokine and Wnt receptors), their mechanism of action and their regulation. • Second messengers: calcium, cAMP and phospholipid signalling. • Intracellular signalling pathways: covering the major pathways in cells (MAPK, PI3K-AKT, mTOR, JAK-STAT, SMAD, IKK-NF-B, Wnt), their components and key roles of protein kinases and phosphatases. • Transcriptional regulation by signalling pathways: roles of transcription factors and chromatin modifications. • Techniques used to research cell signalling.

Written exam: 100% Written exam: Part 1 consists of short answer questions and Part 2 is to write an essay.

In the TBL sessions, students will receive both individual and group feedback.

• Lim, W et al (2014) Cell Signaling. Garland Science. • Hancock, J.T. (2005) Cell Signalling (2nd edition). Oxford University Press

Dr Gino Poulin, Dr Cathy Tournier, Dr Alan Whitmarsh

The year studying abroad is an integral part of the course and must be completed. Some costs, such as tuition fees, are substantially lower. Other costs can vary and are not included in the tuition fee. For example, living costs may be higher or lower than the UK, and there are travel-related costs to consider, such as paying for a passport, visa fees, health insurance, and (if needed) vaccinations.

All students should normally be able to complete their programme of study without incurring additional study costs over and above the tuition fee for that programme. Any unavoidable additional compulsory costs totalling more than 1% of the annual home undergraduate fee per annum, regardless of whether the programme in question is undergraduate or postgraduate taught, will be made clear to you at the point of application. Further information can be found in the University's (PDF document, 91KB).

Students participating in placements outside the UK may be able to apply for funding from the depending on eligibility. Priority will be given to students from low income households.